On show is his concept of the bicycle, which he thought up for a stage production.
But Da Vinci's bicycle chain would end up playing a crucial part in the industrial revolution.
He brought science to art, carefully working out the wingspan of an angel.
One of the most creative spirits of all time, he was also extremely practical.
As an architect, sculptor, scientist and anatomist, he was the original renaissance man.
Da Vinci was born in April 1452 and died in May 1519.
The Brisbane exhibition is open until September the 6th.