At least over 10 policemen were reportedly killed in the blast.
Police sources said that the blast was caused by an explosive- laden truck.
Police have rushed to the scene and sealed off the area shortly after the blast. Rescue work is under way. A lot of ambulances are seeing coming in and out the area, said the sources in Karachi.
At least 40 injured people were admitted into the Civil Hospital in Karachi while some 20 others were hospitalized at Jinnah Hospital in the city, said hospital sources, adding many injured were in critical condition.
Pakistan Taliban (TTP) has claimed the responsibility for the attack immediately after the blast was reported. It also threatened that the next target of attack is the Pakistani president's house.
Thursday night's attack is the second most serious incident of its kind over the last six months in Karachi. Not long before a shrine in Karachi was attacked by a blast, which left over a dozen of people killed and many others injured.
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